PUBLICATIONS

2019

Boettcher M*, Covarrubias S*, Biton A*, Blau J, Wang H, Zaitlen N, McManus MT (2019) Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding. BMC GENOMICS, 20: 107 (*equal contribution). Pubmed

2018

 

Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT (2018) Dual gene activation and knockout screen reveals directional dependencies in genetic networks. NATURE BIOTECHNOLOGY, 36: 170-178. Pubmed

 

Shang W*, Jiang Y*, Boettcher M*, Ding K, Mollenauer M, Liu Z, Wen X, Liu C, Hao P, Zhao S, McManus MT, Wei L, Weiss A, Wang H (2018) Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115: E4051-E4060 (*equal contribution). Pubmed

 

Tromp AT, Van Gent M, Abrial P, Martin A, Jansen JP, De Haas CJC, Van Kessel KPM, Bardoel BW, Kruse E, Bourdonnay E, Boettcher M, McManus MT, Day CJ, Jennings MP, Lina G, Vandenesch F, Van Strijp JAG, Lebbink RJ, Haas PJA, Henry T, Spaan AN (2018) Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin. NATURE MICROBIOLOGY, 3: 708-717. Pubmed

2016

Slabicki M, Lee KS, Jethwa A, Sellner L, Sacco F, Walther T, Hüllein J, Dietrich S, Wu B, Lipka DB, Oakes CC, Mamidi S, Pyrzynska B, Winiarska M, Oles M, Seifert M, Plass C, Kirschfink M, Boettcher M, Golab J, Huber W, Fröhling S, Zenz T (2016) Dissection of CD20 regulation in lymphoma using RNAi. LEUKEMIA, 30: 2409-2412. Pubmed

2015

Boettcher M and McManus MT (2015) Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR. MOLECULAR CELL, 58: 575-85. Review. Pubmed

2014

Boettcher M, Lawson A, Ladenburger V, Fredebohm J, Wolf J, Hoheisel JD, Frezza C, Shlomi T (2014) High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells. BMC GENOMICS, 15: 158. Pubmed

 

Wolf J, Müller-Decker K, Flechtenmacher C, Zhang F, Shahmoradgoli M, Mills GB, Hoheisel JD, Boettcher M (2014) An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation. ONCOGENE, 33: 4273-8. Pubmed

2013

Fredebohm J, Wolf J, Hoheisel JD, Boettcher M (2013) Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine. JOURNAL OF CELL SCIENCE, 126: 3380-9. Pubmed

 

Wolf J, Dewi DL, Fredebohm J, Müller-Decker K, Flechtenmacher C, Hoheisel JD, Boettcher M (2013) A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype. BREAST CANCER RESEARCH, 15: R109. Pubmed

2012

Fredebohm J, Boettcher M, Eisen C, Gaida MM, Heller A, Keleg S, Tost J, Greulich-Bode KM, Hotz-Wagenblatt A, Lathrop M, Giese NA, Hoheisel JD (2012) Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system. PLoS One, 7: e48503. Pubmed

Shenfeld M, Hachmo Y, Frenkel M, Dafni N, Boettcher M, Hoheisel JD, Dotan I, Canaani D (2012) ER-alpha-cDNA as part of a bicistronic transcript gives rise to high frequency, long term, receptor expressing cell clones. PLoS One, 7: e31977. Pubmed

2010

Boettcher M and Hoheisel JD (2010) Pooled RNAi Screens - Technical and Biological Aspects. CURRENT GENOMICS, 11: 162-7. Review. Pubmed

 

Boettcher M, Fredebohm J, Gholami AM, Hachmo Y, Dotan I, Canaani D, Hoheisel JD (2010) Decoding pooled RNAi screens by means of barcode tiling arrays. BMC GENOMICS, 11: 7. Pubmed

 

Boettcher M, Kischkel F, Hoheisel JD (2010) High-definition DNA methylation profiles from breast and ovarian carcinoma cell lines with differing doxorubicin resistance. PLoS One, 5: e11002. Pubmed

CONTACT

Charles Tanford Protein Center

Kurt-Mothes-Str. 3a

06120 Halle (Saale)

Germany

© 2019 by Michael Boettcher Personal. 

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