Welcome to the lab!
Cancer is a group of diseases that is driven by genetic alterations, so called DNA mutations, which accumulate in our cells throughout our entire life. Over the past two decades, researchers have compiled a comprehensive catalogue of all the mutations that can be found in human cancers. This tremendous effort revealed, that out of the more than twenty-thousand total human genes, only a few hundred are mutated in cancer. The major challenge that lies ahead of us now, is to make functional sense of the identified mutations. This is where the recently discovered CRISPR system comes in. This game-changing biotechnology allows us to reversely engineer any cancer mutation into the genes of cultured human cells, in order to study the mutation’s functional impact in-vitro. In our lab we develop precision genome engineering approaches to translate genetic information into novel therapeutic strategies that will ultimately benefit patients that suffer from cancer.